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Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease of childhood. Children with JIA may develop disabling joint disease and sight threatening eye disease. The Childhood Arthritis Prospective Study (CAPS) is a long term project based in five Children’s Hospitals across UK, recruiting children with arthritis in order to find risk factors for severe disease. We will study plasma from these children for immune factors called auto-antibodies that may point to those at risk of severe joint and eye disease who need earlier intervention. The immune markers may yield clues into the cause of disease and more specific therapy.

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Categories

  • Health/Wellbeing Health/​Wellbeing
  • Medical Research Medical Research
  • Beneficiaries

    • Children (3-18) Children (3-18)
    • Young People (18-30) Young People (18-30)

    Situation

     1 in 1000 children in the UK suffer from JIA, the most common rheumatic disease of childhood in western countries.  Children with JIA may develop debilitating arthritis with severe loss of mobility. JIA can continue into adulthood with 50% adults ending up with severe disability.  Between 12-25% of JIA cases develop sight threatening uveitis. Common complications are glaucoma or cataracts with many children developing permanent visual impairment.  The CAPS study along with our £0.5M Big Lottery Fund study are 2 of largest studies worldwide with JIA patients.  Clinical benefit: JIA is a spectrum of disease, there is no specific biomarker for it. £61,767 over 24 months ROYAL NATIONAL HOSPITAL FOR RHEUMATIC DISEASES, BATH

    Solution

    100%
    Categories

  • Health/Wellbeing Health/​Wellbeing
  • Medical Research Medical Research
  • Beneficiaries

    • Children (3-18) Children (3-18)
    • Young People (18-30) Young People (18-30)