RP Fighting Blindness has been very effective in applying its limited funding to stimulate and fund cutting edge research over the last 30 years. However, people with RP need more than research, they want to see the output of avenues of scientific work - such as stem cell research, genetics, microbiology, bionics and understanding growth factors - applied to the development of treatments. This represents a significant shift in the emphasis of the organisation and its beneficiaries, and will only be successful if resources can be applied to attract the very best clinicians to join our very best scientists in the quest to restore sight. Our vision is that we attract enough funds to establish and maintain, for a decade at least, a new department, with exactly this remit. This would mean planning and building the facilities needed, establishing a Chair and lead team, adequate staffing with high calibre researchers, the provision of equipment, and an allocation for overhead and maintenance costs. RP Fighting Blindness would regard such a development as a major, extremely high profile, extremely prestigious project. A doner that chose to finance the venture, we envisage, would remain engaged throughout the decade and could (if so required) also enjoy the related publicity for many years. The project would be designed to attract ministerial, royal, and celebrity associations and our aspirations would be for international recognition. However, it would still be possible for the initial donor to remain anonymous if preferred. The name of the department would be determined by the donor, institution, and the charity in discussion. Efforts would be made to leverage further funds once the major donor or sponsor was identified but without wishing to dilute the impact for that sponsor. For example, it may be possible to attract public funds in the future, and once the team was established other funders would be invited to support both the capital investment and future project work. Potential donors should note that this is a 'ground floor' opportunity, and the initial commitment would be estimated at £250,000 to fund a detailed feasibility study, the development of a comprehensive business plan and a project manager's post for 12-24 months. The project manager would be appointed in conjunction with the donor and liaise as closely with the donor or his/her staff as required. At the point of commitment to the full project a separate accountable board would be set up with representation from the donor as required, and a Chair identified. This is a wonderful opportunity to help RP Fighting Blindness make huge steps forward, to the benefit of millions of people around the world, and to help turn the magic of the science into the magic of sight. Estimated year 1 / year 2 commitment £250,000 Estimated full project commitment £10m - £13m