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Investigating a protein known to be associated with Alzheimer's to expand our knowledge of early disease processes, and develop a target for new Alzheimer's treatments.
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Dr Gunn-Moore has found that a protein called Endophilin I increases its activity in Alzheimer’s disease. The protein is thought to be involved in how nerve cells communicate with each other, and Dr Gunn-Moore has shown that measuring this protein can monitor the progression of the disease. The researchers have a theory of how increased levels of Endophilin I can lead to the death of nerve cells in Alzheimer’s patients, and are now testing their ideas. They will use cell cultures in the laboratory and mice to study the effects Endophilin I has on both molecular systems and behaviour. They aim to verify the role of increased Endophilin I in Alzheimer’s disease. This will improve knowledge of the events happening in the early stages of the disease. They will also find out if Endophilin I has the potential to be a target for new treatments for Alzheimer’s.