Background: Childhood eye cancer (retinoblastoma) is eminently curable, and survival is above 98% in the UK. However, delayed diagnosis, uncoordinated care and lack of family support in developing countries lead to survival of less than 20%. When cancer is present in both eyes, highly specialised care is essential to avoid completely and permanently blinding the child. Care must be nationally co-ordinated to ensure optimal outcomes for all children. This is particularly true in low-income countries, where specialised protocols are available at only one or two hospitals, and access is limited by poverty. Launched in 2008, the KNRbS project aims to build a sustainable, locally managed retinoblastoma program for Kenya and the wider Eastern Africa region. This program will optimise the use of currently available resources, while reducing financial burdens and improving quality of life and prognosis for affected children. The KNRbS Group is a multidisciplinary team of 70 medical professionals (ophthalmologists, oncologists, pathologists, paediatricians, pharmacists, nurses), social workers and parent representatives. 18 hospitals (public, private and all mission eye hospitals) from across the country are involved in the program. Finances and geography prevent frequent face-to-face collaborative development, and most communication is carried out via the internet. The annual intensive three-day meeting is therefore essential to refresh and strengthen the collaborative environment that is necessary to achieve structured national care and optimal outcomes for individual children. The Annual Meetings enable the KNRbS Group to: 1) expand local knowledge and understanding of effective retinoblastoma management in the resource limited setting; 2) build and implement national awareness initiatives that achieve early referral and diagnosis, and develop treatment protocols that maximise opportunities for cure and enhance quality of life for affected families; 3) continue collaborative development of national guidelines that achieve optimal care with available resources; and 4) advance realistic programs that respond to the needs of children and families who currently struggle to access timely, appropriate care. Each of these elements is enshrined in the national framework established in 2008. The full report of this can be downloaded from: http://www.daisyseyecancerfund.org/Files/Reports/ratischallenge3.pdf The 2008 KNRbS Meeting (Atthi River) was co-funded by the Sir Halley Stewart Trust and the Canadian Institutes of Health Research (Meetings, Planning, Dissemination Grant: Global Health).. The 2009 KNRbS Meeting (Mombasa) was co-funded by The Kalmar Family Foundation through DECF-Canada, with generous support from Sarova Hotels and Kenya Airways. Will you be part of this vital program that builds lasting high quality care for children with cancer in Africa? Costs: Full cost of the 2010 three day meeting (to be held in Nanyuki) for 70 delegates is £32,500 (£465 per person), based on exchange rate of £1 = 117 Kenya Shillings (25/03/10). This includes travel and accommodation bursaries and lost-salary reimbursement for Kenyan delegates, to ensure no member of the KNRbS Group is unable to participate for financial reasons, and international travel for 5 retinoblastoma specialist facilitators from the UK and Canada.