Action Medical Research

Brain cancer - medulloblastoma and disease relapse

Investigating the mechanisms of disease relapse in medulloblastoma, a form of childhood brain cancer, with the aim of improving survival and developing future treatments.

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It ran from 12:00 AM, 1 February 2011 to 12:00 AM, 1 July 2014

Registered Charity in England and Wales (208701)

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Situation

Medulloblastoma (MB) is the most common malignant brain tumour of childhood affecting around 100 children each year in the UK. It is one of the largest contributors to cancer deaths in children with survivors often suffering therapy related long term health problems. Sadly, in around 40% of patients treated for MB the condition will recur. The majority of patients with relapsed medulloblastoma will die from their disease, as most existing treatments for relapsed MB can only prolong life.

Solution

This project will look at the clinical, pathological and genetic features of relapsed MB, which will provide essential insights into the biological mechanisms underlying disease relapse.